Cultural and environmental Issues in Pakistan Essay

Corruption is the prime reason behind the economical unstableness. Corruption has spread into the world and has ruined the economy. Pakistan has been ranked at 42nd number among the most corrupt nations of the world. Unemployment: Unemployment is a major social problem caused by poor economical system. Causes of unemployment are: Lack of funds followed by unorganized system and lack of new projects are causing unemployment worldwide. There are many reasons of unemployment like influx of machinery that has replaced manpower. Health problems: Health is another social problem caused by poor economical conditions. The cost of living is ever increasing and shortage of funds is a usual problem worldwide. There are less hospitals and medical centers and if there are any, the people are unable to afford their and their children health  expenses So the health problems grow unchecked. Child labor: Children who deserve to be educated are forced to do work.  The circulation of money is restrained to rich people only causing the poor to become more poor. In past, some countries refused to import those goods from Pakistan in whose making children were employed. Due to growing inflation (rise) and poverty, parents are bound to send their children to work to light their stoves. Economical problems: 1. Power crises 2. War on terrorism 3. Declining export 4. Tumbling stock-market 5. Lack of tourism 6. Loss in business Power crises are affecting the economy of the world very badly. The power crisis is followed by decline in production and at the end the economy of the countries is affected badly. We are running short of fuel worldwide. All the countries are affected by power crises. War against terrorism is another very important reason behind the economical problem.ï‚ § War is affecting the world’s economy and is causing problems like shortage of fuel, lack of funds, increase in health problem etc. War benefits none, someone is hurt badly and someone is destroyed completely. Lack of power followed by decline in production is the main cause of declining export which is a major economical problem worldwide. In Pakistan, core inflation soared to 18.85% in first quarter of year 2009. The production cannot even fulfill the demands and hue to decline in export and lack of trouble, the world economy is suffering great problems. The stock-market is suffering a decline worldwide. Lack of investment and poor economical condition of the people and government is another cause of decline in stock-market worldwide. In 2009, many times Karachi Stock Exchange has plunged to its lowest point in the history of Pakistan. Lack of tourism is also a cause of the declining in economy. Local as well as foreign media has projected Pakistan as a dangerous and unsafe country. Its poor law and order situation has alarmed the tourist and thus Northern areas no more receive many tourists. The poor  economical system affects the business very badly. Foreign investors are not ready to setup their businesses in Pakistan. More than 70 Multinational Companies have already packed up their business from Pakistan. Government as well as every single citizen has to play its own specific role to b ring about a positive change. Cultural crisis in Pakistan A SUFI saint has defined culture as the fragrance left behind when the incense stick of life has burnt out. And, heritage is valued as the highly prized family silver — a loan from our ancestors to be passed on to future generations. No department of life – be it economic, cultural, religious or recreational – has been free from the effect of this great transformation in progress. The old system of classification and stratification of society as a whole is changing gradually and slowly but surely and certainly. We may go for some little changes. For instance, we may change clothing style. We may change our room setting. We may change our eating stuff. We may do whatever makes us happy. Movement is the stuff and essence of life, both for individual and the society. From the independence day of August 14, 1947 up to date, Pakistan’s has been a society in transition. The society of Pakistan is dynamic and therefore ever-changing, and its patterns are changing transforming from time to time. The national society has been responding to the challenges of environment, natural and man-made. The factors and circumstances responsible for these changes can be enumerated as below; partition of sub-continent, technological and scientific inventions, growth of urbanization and industrialization, expansion of commercial activities and international trade, changes in the economic structure of the country initiating the industrialization of its economy, the spread of literacy resulting in the rise of a secular intelligentsia, the effect of the spread of different ideologies of different political parties in the country, the impact of the highly developed countries of the world on our society, the working and influence of the trade union and co-operative movement, the expansion of the area reached by the mass media of communication like radio, press, cinema, television etc. migration and finally cultural diffusion. Changes are the spice of life. Is it true? Of course YES! It is true because everybody needs a change in whatever he/she is doing. We want changes around us. Monotonous life just makes us feel  bored. It is good to have a change. It is not important that we should go for big changes everyday. We may go for little changes that should be pretty affordable. If we are seeking for a healthy and entertaining life then changes are very important. Changes must be positive. If we will go for negative ones then they will obviously have a negative impact upon our lives. Negative impacts are accountable for some more negative changes so we need to be assiduous in this regard. Pakistan today is undergoing an identity crisis a crisis which the author feels arises from culture conflict. One of the causes of this conflict is that the Pakistani society possesses imported cultures along with its own; varying with the diverse regions. The numerous cultures tend to conflict with one another. This crisis is clearly manifest in the actions of the Pakistani you th –rebellions, and indecisiveness. The struggle for Pakistan was a unique historical experience with few parallels in the annals of history. It transcended ethnic ,linguistic, cultural and regional differences and coalesced into a powerful movement culminating in the creation of an independent homeland for the Muslims of the sub-continent. It even defied the geographic compulsions. In essence, it was an experience of a deep Muslim consciousness which both inspiring and invigorating. However ,Pakistan after its creation was, indeed ,and ethnically plural society. Pakistan, these days is passing through a crucial era of multifarious ethnic problems; multi-lingual and regional; problems etc. The province of the Punjabi has three distinct ethno-linguistic groups i.e. Punjabi ,Potohari and Saraiki speaking .Of late ,there has been a nascent rise of Saraiki consciousness with a demand for a separate Saraiki Province comprising of Saraiki speaking areas . In Baluchistan the Baluch , Brohi and Pakhtoons are dominated ethnoligual groups. The wide spread nationalist consciousness of Balchusitan has cut across the tribal divisions. In the North-Western Province of Pakistan ,apart from Pushtu,Hindku and Saraiki are also spoken in some parts of this province .The Pustoons as an ethnic group are integrating with the economic life of the rest of the country .The issue of Kalabagh Dam has arisen out of the same ethnic issue and provincial disharmony of Pakistan in the province. Though the proposed dam may play the role of key factor in the prosperity of the country and may breath a new life in the agricultural and industrial life of Pakistan .Moreover the  ethnic groups of the province also demand regional and to rename the province as Pakhtoonistan. Similarly the problem of ethnicity in Sindh is very complex. It is a web of discards, clash of interest and the resultant sense deprivation between the different ethnic groups. Overawed bewildered conditions, the inhabitants themselves ,sometime become bewildered and the frequent out –burst of violence creates hysteria among the people which consequences which are damaging for the peace and harmony of the province and also for the nation as a whole. All cultural activities can be perpetuated through private-sector support by providing incentives and tax breaks. Let there be encouragement by the government for partnerships of commerce and culture, for promoting a positive, cultural image of Pakistan. The government needs to do a lot, but it needn’t do it alone — through a strategic plan each Pakistani can be encouraged to become a cultural worker. Pakistan is today at a crossroads due to challenges posed in the post 9/11 world — the world of so-called clash of civilizations — with an increasing polarization between the Muslims and the Western world. The affect of negative images flashed around the world can only be counter-acted through a cultural offensive. To achieve our objective of becoming a favored country for investment, culture will need to be placed at the core of our development policies and propagated with every possible means. It is not only political and diplomatic strategies that will create a better image for our country, but equally the propagation of our cultural agenda that is likely to pay dividends. Let us promote our vision of a cultural Pakistan, Saqafati Pakistan, to provide another window to our country, a world removed from violence and negativism, promoting instead an image of a pluralistic Muslim country, a depository of rare cultural assets, along with historical memories and spiritual orientation of its people. Each public sector organization and private sector, too, can be engaged in promoting our cultural resources, through even simple means of films, posters, images and leaflets: PIA within aeroplanes and national and international offices, Pakistan Railways by utilizing its countrywide stations, Pakistan Post Office through its innumerable outlets, the technological gateways and countless websites, to name a few. Let us not fritter away our family silver and the fragrance of the incense stick, but safeguard them and utilize them for creation of a cultural Pakistan, for not only development and well being  of our people, but also for social and economic advancement of our nation. Environmental issues: Water pollution from raw sewage, industrial wastes, and agricultural runoff; limited natural fresh water resources; a majority of the population does not have access to potable water; deforestation; soil erosion; desertification. Little attention was paid to pollution .Some are these Related concerns, such as sanitation and potable water, received earlier scrutiny. In 1987 only about 6 percent of rural residents and 51 percent of urban residents had access to sanitary facilities; a Greater success has been achieved in bringing potable water within reach of the people; nearly half the population enjoyed such access by 1990. However, researchers at the Pakistan Medical Research Council, recognizing that a large proportion of diseases in Pakistan are caused by the consumption of polluted water, have been questioning the â€Å"safe† classification in use in the 1990s. Even the 38 percent of the population that receives its water through pipelines runs the risk of consuming seriously contaminated water, although the problem varies by area. In Punjab, for example, as much as 90 percent of drinking water comes from groundwater, as compared with only 9 percent in Sindh. The central government’s Perspective Plan (1988–2003) and previous five-year plans do not mention sustainable development strategies. Further, there have been no overarching policies focused on sustainable development and conservation. The state has focused on achieving self-sufficiency in food production, meeting energy demands, and containing the high rate of population growth, not on curtailing pollution or other environmental hazards. In 1992 Pakistan’s National Conservation Strategy Report attempted to redress the previous inattention to the nation’s mounting environmental problem. Drawing on the expertise of more than 3,000 people from a wide array of political affiliations, the government produced a document outlining the current state of environmental health, its sustainable goals, and viable program options for the future. Of special concern to environmentalists is the diminishing forest cover in watershed regions of the northern highlands, which has only recently come under close scrutiny.

Best Practices in Hr- the Journey of Tata Group

Businesses thriving in harsh environment have an ideal higher than personal profit. There is a common thread that drives them forward for years. This common thread is represented in the core values established by the founding fathers. Businesses that integrate people with the broader goal of sustainability by this common cord are those that live. There is a pioneer of these value driven business practices in the history of corporate India, the TATA group. Understanding the journey of Tata group in the perspective of HR practices can help us examine the role of people or employees in the success of an organization.For this let us understand the core values of the founding father of this business community. [pic] [pic] Jamsetji started the business when India was entering the final phase of colonization. Having met with obstruction and harassment in pre-independence India he adopted a new ideal for his business ‘Community capitalism’. According to eminent Japanese scholar Haruo Funabashi ‘Jamsetji had a more holistic perspective, however. His focus was not the trees but the forest—that is, not the individual stakeholders but the community in the largest sense’.All his efforts whether building a world class hotel or sprawling townships, had been aimed at the greater good of community and nation. Community capitalism is a ‘people first’ approach to business. Jamsetji was the stalwart of HR innovations. In a time when workers were treated as ‘Cogs in wheel’, he voluntarily considered their functional limitations. He provided them with benefits like eight hour working day, free medical aid and maternity benefits long before the government mandated these provisions.By aligning his business aspirations with nation building he engaged in greater community development. All this contributed towards creating a motivated workforce. [pic] The ideals of Jamsetji were carried forward by subsequent Tata leaders. Each le ader synergized these core values with new ones that were the call of his times. JRD Tata sometimes referred to as ‘Chairmen’s chairmen’ brought about a ‘value shift’ in the HR practices. He was a strong believer in a merit and believed in professional management of the group companies.It was this conviction that led him to steer the policies from Human Resource management to Human Resource development by nurturing leaders. His commitment to merit and professionalism ultimately led him to form Tata Administrative services and Tata Management training centre that became breeding grounds for future business leaders. His vision served the group well. Russi Mody, Sumant Moolgaokar and Darbari Seth became beacons of Tata leadership and were instrumental in generating wealth for the group and the country.JRD also understood the crux of successful labour relations. Tata steel became one of the first companies to have a dedicated Human resource department to make workers feel valued after there were frequent tense labour situation despite being treated exceptionally well; indicating worker discontent. JRD was quick to sense that workers had started to feel like parts of a machine. So he made them feel wanted by forming a department just for them. This is why Tata group is considered champions in personnel relations. [pic]The next generation witnessed Ratan Tata’s phenomenal leadership that coincided with unprecedented economic liberalization in India. He envisioned a strategic plan of institutionalizing a stronger collective identity of the Tata group in changing times. The new value he created can be held as ‘Osmosis’, a process of conveying cultures, beliefs and values across group. Efforts like displaying a common logo helped to ingrain common ethos in all Tata companies. But a bigger change had to be dealt with too, The Changing employee aspirations.Ratan Tata soon realized that the generation of employees he is dealing with wanted personal growth and career advancement. Ratan Tata aligned these personal pursuits with business goals by HR practices that can fall under ‘Disruptive innovation’. Integrated HR system, BSC, Brockbank model, HR gurukul, TBEM etc are all part of this alignment. Some may argue that such performance oriented system is against the core values of Jamsetji, who never believed in punishing the weak and rewarding the strong.But it cannot be ignored that with their present policies Tatas do reward the best but do not punish the weak. Performance based layoffs in Tata group are highly uncommon. To sum up Ratan Tata’s vision of Osmosis has only strengthened the foundations of Tata values across group. This belief is mirrored in the chivalry displayed by the Taj hotel staffs during the terrorist attack that was preceded by similar acts of the staff of another Taj group hotel in Maldives during the Tsunami in 2004. The future for both these companies thro ws the challenge of working in a Flat world.With the Tatas going global with M;As and software industry expansion communicating common values across cultures has become a problem. HR initiatives to meet this challenge are yet to be seen. The future roadmap for HR practices in the Tata group should account for the cultural dimension. The HR heads should also be prepared for a new generation of potential employees that is being prepared by a changed society and educational environment. Gauging needs and ambitions of this generation is especially important.Moreover with a change in top leadership this year speculations are high on the changes in HR management of Tata group References Toward a Sustainable Business Model for the 21st Century Haruo Funabashi www. tata. com – visited on 10 September 2012 ———————– BEST PRACTICES IN HR- THE JOURNEY OF TATA GROUP ‘THE OSMOSIS’ – PERPETUATING CORE VALUES ACROSS COMPANIES AND CULTURES IN TATA GROUP ‘THE VALUE SHIFT’-FROM HUMAN RESOURCE MANAGEMNET TO HUMAN RESOURCE DEVELOPMENT ‘COMMUNITY CAPITALISM’- BUSINESS AIMED AT COMMUNITY BASED DEVELOPMENTFORNATION BUILDING ‘In a free enterprise, the community is not just another stakeholder in business, but is in fact the very purpose’ –Jamsetji Tata â€Å"To be a leader, you have got to lead human beings with affection† – JRD TATA ‘’One hundred years from now, I expect the Tatas to be much bigger than it is now. More importantly, I hope the Group comes to be regarded as being the best in India, best in the manner in which we operate, best in the products we deliver and best in our value systems and ethics’’ – Ratan Tata

The Reign of Charles V

Charles V reigned over a vast empire in a tumultuous age. The New World was a relatively recent discovery, and several other factors point to the idea that Charles V's reign coincided with a global transition into the modern age. Although Charles V's focus was primarily domestic (in the sense of Europe and the surrounding territory), the meeting of traditional values and modern ideology was one of many issues Charles faced, independence was another. Consolidating and re-consolidating his power was a problem that sapped much of Charles V's, and by extension his empire's, time and resources. From the papacy to the fiercely independent German coalition of prince-states, Charles often to had to take extra measures to enforce his policy in an empire that varied greatly from one polity to the next. Religion was another obstacle faced by Charles. The Protestant Reformation (steeped in the last vestiges of a somewhat anti-clerical Renaissance movement) appealed to many not only as more pious faith, but as a tool to be used for political maneuvering and opposition against an emperor whose motto was â€Å"Further beyond† (in regards to spreading the Christian faith). These concerns coupled with the always-present threat of foreign invasion made ruling over his empire an incredibly demanding and difficult task. Add to that the largely impractical and complex political process of the time, the question of finance, and a peasantry discontent synonymous with the values of the modern age, and you have a long and arduous list of problems faced by Charles. Although Charles the V was focused primarily on reform and maintenance rather than expansion, his conquering of the Aztecs and Incas can be considered brutal success and added greatly to the territory of New Spain. Cultural, economic, and political disparity throughout the empire, the search for financial backing (as well as questionable fiscal habits), foreign threat, and the problem of enforcing his often conventional policy in an era of change make the reign of Charles the V one worth studying. The empire preceded over by Charles encompassed many different cultures and made the vision of one wholly unified political entity hugely unfeasible, â€Å"By tradition he ruled only with the consent of the Imperial Diet, whose sheer size and diversity of interests made agreement almost impossible† (Maltby 22). As heir to not only the Habsburg dynasty, but a host of other territories (some of which his authority was unrecognized), Charles had to undertake the task of administrating over unique polities that themselves had issues administrating. Peasant unhappiness had long been an issue in medieval Europe, and combined with the scarcity of labor (due to the Black Death) peasants took on a new feeling of self-worth and importance. This often culminated in open revolt and passive resistance when the peasant class's demands were discarded as usual. This caused issues in management for the individual polities and on a larger scale for Charles. Charles had to deal with a huge difference in political process between any given polity, from the loose organization of the German States to the Cortes. Charles dealt with this largely on a by-issue basis, choosing to solve one problem at a time. This was in line with Charles's cautious nature, for a decision made to solve one problem could not be considered without regard to how it would affect the others, such is the nature of the interconnected problems facing him. Even unifying factors such as the church had trouble bringing together polities that were more often concerned with individual well being and privilege then with the welfare of the empire. Charles had too many issues too deal with at once, so he employed viceroys (regional governors) as extensions of imperial will. Many of Charles' problems stem from the lack of a unifying force in the empire, as unrealistic as it would be to imagine one at that time. A constant and expensive threat faced by Charles was that of foreign invasion. Charles was faced with defense of a â€Å"Vast patchwork of principalities that were neither geographically contiguous nor similar†¦ in culture or tradition† (Maltby 8). The frequent clashes with France and it's monarch Francis the I mark the most prominent campaign in â€Å"terms of blood and money† (Maltby 32). Charles developed a personal rivalry with Francis as evidenced by his repeated offers to settle huge disputes with a duel. Sometimes called the Habsburg-Valois rivalry, France was located dead in the center of Charles's empire. And with France's resources and military ambition rivaling that of Charles, conflicts between the two were frequent and costly. France's interest in the Italian peninsula fueled it's military conquests and was a continuation of French interest in the area dating back to Charles VIII's invasion in 1494. The French were defeated in 1525 (culminating in Francis's capture and the treaty of Madrid), inconclusively in 1529 (leading to the Treaty of Cambrai), and again inconclusively in 1538 with a truce (although the conflict would later start up with a renewed Frankish-Ottoman alliance). Charles owed much of his military success to his elite corps the tercios, a cohesive combination of â€Å"pikes with shot.. that would dominate European battlefields until the Thirty Years War† (Maltby 40). Some of the war successes and failures during conflict were directly related to advance in technology such as the bastion. Another threat, and one that endangered his very values, was that of the Islamic Ottoman empire. Starting out as one of many Christian raiding advocates of Islam, the Ottoman empire made territorial acquisitions at an alarming rate, especially alarming to the heavily Christian population at the time. The Ottoman empire found an able leader in Suleyman â€Å"The Magnificent† whose campaigns ended twice at Vienna due to logistical reasons. Failure to conquer the entirety of Charles's empire did not stop the sultan from dominating the Mediterranean and also unleashing the pirates upon Charles, some of who caused serious issues for him (Barbarossa) via harassment and guerrilla techniques. Charles's conflict with religion can be seen in his dealings with the Protestant Reformation (and a general anti-clerical position) as well as his subjugation of the papacy. Holding the title of Holy Roman Emperor had personal meaning to Charles, and his actions were often motivated by his desire to advance and protect the Christian faith. He met with opposition by not only the Protestant Reformation, but by a rebellious papacy concerned first with its own survival and second with the Christian faith. Although the papacy under Clement VII was largely pacified by instilling the Medici in Florence, the Reformation was not so easily quieted. The values behind the reformation attracted opportunists, condemners of the church, and peasant revolts alike, but the movement found a special foothold in the Germanic provinces. Besides using the new religion as a means of resisting imperial control, the princes had a more practical motivation, that by breaking with the church they could â€Å"Increase their revenues, strengthen their reserves of patronage, and gain control of†¦ institutions†¦. without alienating their subjects. † (Maltby 49). Actual proponents of the movement believed that it â€Å"offered a truer interpretation of the Gospels than that provided by the traditions of the Old Church† (Maltby 49). Whatever their justification, Charles V adopted a number of different stances concerning the Protestant Reformation. Domestically, the Inquisition was still active, and destroyed Spanish Protestantism (what little there was), and they also persecuted effectively any other movement that strayed from the accepted doctrine of the time. Concerning his less secure territorial acquisitions, Charles's stance ranged from tolerance to viewing Luther's doctrine as â€Å"False† and â€Å"Evil†, but the conflict manifested itself in the struggle between the Protestant formed Schmalkaldic League and Charles. Formed to be a united Protestant front against the still majority Christian Orthodoxy, The League was allowed to exist only as long as Charles was busy with the Ottomans. Once that threat had been neutralized (via treaty), Charles turned his attention elsewhere, namely to what he viewed as religious rebellion, the Schmalkaldic League. Charles, backed by papal troops, eradicated the league (who was plagued by authoritative indecisiveness) in a fashion reminiscent of the crusades. However the ever-present problem of enforcing his policy appeared in Charles's victory over the league. Many of the prince-states that re-converted remained largely protestant in population, placed no constrictions on the spread or practice of the faith, and some outright reverted back to Protestantism. Charles's legacy is often tainted by his fiscal actions. The empire needed mass amounts of money not only to function, but to finance Charles's martial actions. Charles's often depended on the system of redress after compensation, expected donations, and random windfalls. But by far his most relied upon source for money, were the banks. Charles borrowed heavily from many banks to support his endeavors. Often Charles could not repay the loan by the deadline, which led to a slew of re-negotiations, raised interest rates, and fees instituted by the banks to ensure profit. The relationship between them was initially symbiotic. Charles needed money and the banks were happy to profit off of the high interest rates and continued to supply him even when his credit dropped in the later years of his reign. Later in Charles's reign however, the banks realized he was no longer a safe nor profitable investment, which often forced him to resort to coercion to get the necessary funds. The diverse nature of the problems meant that no one solution would encompass the broad spectrum of issues facing Charles and his empire. Ranging from financial troubles, to foreign threat, to having core values that conflict with the changing times of that age, Charles allowed caution and his deep Christian values to guide him through those troubled times until his abdication and retirement to a monastery. Charles' reign certainly had its share of successes and failures, and Charles has been described as â€Å"not quite a good man, and not quite a great man† (Maltby 129), but he is certainly one worth re-examining, even four centuries later.

Case study Essay Example | Topics and Well Written Essays - 750 words - 24

Case study - Essay Example In this case, resources such as time and management costs have been taken into account and through the initiative, the total cost of keeping neighborhoods and communities safe are spread across a continuum of responsible entities (CESAR, 2001). Prior to initiatives like this, the justice department which comprises of the courts and the police was tasked with overlooking the security of the community. However, following increased population and development of real estate structures, the eyes of the justice system cannot keep the communities safe. If more police officers are to be recruited into the force, more funds will be needed despite the fact that national security budget is at all-times high. The collaborative initiative offloads some of the responsibilities expected from the justice department helping to conserve resources that can be used in other sectors. Additionally, the collaborative initiative helps in the recovery of communities categorized as HotSpots as they help residents to regain normal lives and to adjust to the limitations on their lifestyles (CESAR, 2001). Among the partners in the collaborative initiative include police, members of the community, and prosecutors as well. However, based on the structure of the initiative such that it aims at making the best out of the community members, the role played by prosecutors is undermined by the very objective of developing the initiative. Members of the society look forward to participating in the initiative but the presence of prosecutors projects a rather negative image regarding the role of the initiative. For instance, under the community prosecution results of the initiative, it shows that prosecutors were included in the initiative to draft and implement judgments and sentences that suit the community. In one way, this approach is acceptable as it ensures that communities with less resources and thriving as lower class would not be subjected to

Horseradish peroxidase assay Lab Report Example | Topics and Well Written Essays - 1500 words

Horseradish peroxidase assay - Lab Report Example For each enzyme there is a small of range of pH within which it works optimally. Enzymes have  active sites in their structures. The active site is the part of the enzyme that has the correct shape and the functional groups required to bind to the substrate (Dunford, 1999). Enzyme activity can be measured in any one of these two ways: observing the rate at which the substrate disappears during a reaction or measuring the rate at which the product is formed. Enzyme assays are used in such measurements. There are two methods that have been developed for use in measuring the amount of substrates or products in a chemical reaction: continuous and fixed-timed assays. Continuous assay make use of a spectrophotometer to measure the rates at which the substrate disappears and products form in real-time (Leskovac, 2003). To measure the peroxidase activity a change in the amount of product formed will be evaluated over time. For the breakdown of peroxide by peroxidase, the simplest molecule that can be measured is O2 gas, the product of the decomposition of peroxide. To accomplish this the real volume of O2 gas produced is measured by use of an indicator. For this experiment an indicator (pyrogallol) that shows the presence of O2 gas will be used (Dunford, 2010). 2.50 cm3, 0.35 cm3, 0.10 cm3, and 0.35 cm3 of deionized water, buffer solution (at a pH of 6.0), hydrogen peroxide, and pyrogallol respectively were pipetted into two separate cuvettes labelled Cuvette 1 and Cuvette 2. The contents of the cuvettes were then mixed well using a small glass rod. The spectrophotometer was set to 420 nm after which Cuvette 1 was placed into it. 0.1 ml of the buffer solution was added to the cuvette and then stirred using a small glass rod. The readings of the spectrophotometer were recorded every 10 seconds for 5 minutes. Cuvette 2 (blank) was placed into the spectrophotometer. 0.1 ml of

Integrated Project Management Tools Research Paper

Integrated Project Management Tools - Research Paper Example At the project’s starting stage, the project is explicitly and clearly defined. The scope of the project and its purpose are defined, and a benchmark for the expected final product is set. The time and resources required for completion of the project are allotted. Resolving problems encountered during the project and controlling the product quality are the main activities of a project’s control stage (Bainey, 2004). This stage oversees the completion of most of the work, and it is during this stage that most of the project’s time is consumed. The project’s closure level involves officially ending the project and providing any useful tips applicable to other projects. Any outstanding work that requires completion is done in this stage. The Project Manager is responsible for managing the basic factors of a project simultaneously; these include time, scope, resources, and money (Schwalbe, 2010). These four elements work hand in hand, and for the project to be a success, these elements must be managed together. In a bed and breakfast project, the resources include equipment, funding, people, facilities, or materials. Management Tools Work Authorization System This is a method used in hand with project management. The project manager together with his designees uses the work authorization system to sanction all project work during a project management. Work authorization procedures show the person responsible for authorizing activities to be completed and how those authorizations may be achieved (Schwalbe, 2010). These procedures include documents that must be filled before initializing any work, and the possibilities of any prerequisites. In order to facilitate the efficiency of project management in bigger projects, work authorization systems detail the timeline of the project. For example, the work authorization system might show when some parts of the project should end, by whom and in which order (Bainey, 2004). For a bed and breakfa st project to be successful, work authorization is an effective tool. Project Status Report It is a regular, official report on a project progress against the plan of the project. Its purpose is to efficiently and effectively communicate the project status at regular intervals. In addition, it can be utilized in providing a documented history of a project. Objectives of a status report include communication of the project progress, simplifying the mode of collecting and distributing project information, improving passing of information within the project, and improving organizational support of the project. A good, consistent project status report prevents a project from missing completion deadlines by keeping the project on the early-start and early-finish schedule. Being alert of the start and completion dates during a project increases the chances for the project being successful. A project status reporting is a function that is performed throughout the project (Barkley, 2006). S cheduling System A scheduling system is a form of a tool used to build an integrated project management system. A good scheduling system should aid in achieving the best end results in a bed and breakfast project. The project manager should ensure that the scheduling system

Medical Experiments on Incompetent Individuals in a Society Essay

Medical Experiments on Incompetent Individuals in a Society - Essay Example Many factors are important and need to be taken into consideration while a problem of this intensity is being discussed. The divisions in the society need to be taken into account. Racial differences and how intelligence in different races and societies are assessed is an important aspect of such a debate. One must also assess the question as to who possesses the right to assess the intelligence of people who are to be subjected to medical experiments. What constitutes intelligence also remains an important part of this debate that would decide the future of human society. Much of this debate can be argued to stem from the work of the great naturalist, Charles Darwin, who argued that in a world where the natural resources that is available to everybody is limited, the law of the ‘survival of the fittest’ would be the one that holds (Darwin). ... The fact that such reforms can be brought about or stalled only through the medium of legislation by the executives of nations makes the issue even more complicated. This is because the issue, like the legalization of abortion or animal rights, is an extremely sensitive issue and can create problems for political parties that usually take the decisions of the executive wing of the government of a nation state. Public perceptions are thus, an important part of this debate. An objective approach that brings people from various backgrounds together for negotiations would be the best way to seek a solution for this problem. This should be preceded by campaigns that seek to allay the fears of all sections of the society regarding this matter. This paper shall seek to look at the complexities of the issue at hand and examine the choices that are available to human society as a whole for the purpose of attaining a solution to this problem. The issue of whether people who are in states of co ma where they may not be able to inform others of their assent or dissent to be a part of a certain experiment conducted for the purpose of finding out the efficacy of a certain scientific or medical truth, is a complex one. What constitutes death for such people is a question that has not met with satisfactory answers from philosophers as of yet. People who have died may have, in their wills, decided to donate their bodies for the cause of medical research. The question of death, thus assumes importance in this matter. Also important is the assent of the person involved. In many cultures, the body of a person is considered to be important for the performance of the last

Person Who Made an Impact in My Life Essay Example | Topics and Well Written Essays - 750 words

Person Who Made an Impact in My Life - Essay Example He had also lived a moral life, that his integrity is beyond reproach. He is also a very good family man. He has a wife who loves him and whom he loves back, with children who equally loves and respects him and are also motivated to excel in their chosen fields of endeavors. This is the reason why I kept on pushing myself to do better in school and to study different fields of endeavor because I know that to do good in my chosen career, I have to prepare myself well through a good and multi-disciplined education. As a student, my uncle was a scholar and had different degrees. His academic preparation enabled him to excel in his chosen career. I am doing the same thing today. I am trying my best to do well in school and to expose myself in the different field of studies to make myself a well-rounded professional when I have graduated later and embarked on a professional career. I consider myself lucky because I realize this lesson early in my life. I know that all this hard work, all this perseverance that I am exerting will pay off when I graduated in school because this will prepare me well to excel in my chosen field of endeavor. I am hoping that when I have already graduated in school, I will be successful like him both in my professional and personal life. Essay B: The Recent Financial Crisis (issue of importance to me) When I ask what recent issue I consider important that has significance to me, my family and the community at large, I cannot help but talk about the recent financial crisis. The crisis made the lives of a lot of people difficult. There were people I know personally who lost their jobs and their homes, and young as I am, I felt how desperate the situation was. Perhaps the recent financial difficulty that everybody experienced during the recent crisis made the young people in this generation to mature early. We began to worry about our future and this country when we only used to think about ourselves. Suddenly, we were thinking about politic al issues and responsibilities because we saw how some families disintegrate with the crisis and cannot help to wonder how the crisis happened. People of my age became aware and realized how vulnerable our country to crisis. When we begin to think like that, perhaps it is safe to surmise that we matured early. Personally, the recent financial crisis sparked my curiosity to inquire about what caused the crisis that made people lost their jobs and their homes. I was dismayed to know that the root cause of the financial crisis was the greed of a few people that eventually took the toll in our economy. I will no longer discuss the details of the root cause of the crisis so as not to consume space in this paper but suffice to say that had the financial professionals been ethical in their practice and considered beyond themselves, the crisis would not have happened. In a way, my inquiry on what caused the recent financial crisis had taught me how important it is to be ethical in our profe ssional practice because a profession’s collective misdemeanor will have an impact not only in their respective industry but also on the economy as a whole. I learned that the lack of ethics in ones professional practice will make people distrustful not only in our industry but also in our economic system as a whole.  Ã‚  

USA economy Essay Example | Topics and Well Written Essays - 1000 words

USA economy - Essay Example of the most important responsibilities of the Fed is to ensure monetary stability in the economy, which can be achieved through a combination of stable prices of goods and services across the economy coupled with a low inflation level and level of confidence of the investors in the currency of the country. The Fed comes out with monetary policy in order to ensure a certain key objectives like delivering price stability with a low inflation level coupled with an objective to support the Government’s economic objectives of growth and employment. To understand how the Fed monitors price related regulations to keep a check on inflation, we may consider a small example of the regulation of house and property prices. To take any decisions related to interest rates keeping in mind the ongoing inflation rate, the Fed must be thorough with the booming property prices and must take steps to ensure that the prices are not artificial. Government intervenes through its central bank to regulate the prices of many commodities, similarly it also regulates the prices of houses like any other important commodity. Fed has the responsibility to keep a check on asset prices including the prices of houses. There can be a number of reasons why the prices of houses may shoot up, like the simple rule of demand and supply has a definite impact. (Demand and Supply for Housing). The central bank sets a fixed interest rate at which it lends money to financial institutions and depending on this interest rate, individual banks and other financial institutions set up their own interest rates, which apply to the whole economy. This step is of indispensable importance to the economy, as this is very widely used to contain inflation. The only purpose behind such a step is just to contain undue inflationary levels prevailing in an economy. The point to be noted here is that, this interest rate set by the Bank of England is so effective and powerful that it chips in greatly to regulate the whole

Long Live The Infoperneur Essay Example for Free

Long Live The Infoperneur Essay In the wildly popular 1960’s American television series Star Trek, Captain James T. Kirk would often turn to his engineer, Officer ‘Scotty’ Montgomery and direct him to take the spaceship into a fascinating new realm called ‘warp speed’. With commanding confidence he would turn to Scotty and say â€Å"Warp speed ahead†. â€Å"Aye Aye Captain† the Scottish officer would reply, at which point millions of ‘Trekie’ fans around the world would simply gasp with unparalleled excitement as the international crew was suddenly thrown back against their seats, as the spacecraft instantly hurled itself at an unprecedented speed through an unknown galaxy. Over just the last few years, we have witnessed a moment when art in a sense, has shown itself to imitate life, as tomorrow’s future has been rapidly hurled into the lap of our present; so to speak. The entrepreneurial spirit of old has been overtaken by a new spirit of innovative ‘inforperneural’ dynamism. At the very same time the â€Å"technology of yesterday†, as the Black Eye Pea’s will. i. am says, has been replaced by the â€Å"technology of tomorrow† (Huffington, 2008). The actual technology favoring this dynamic â€Å"exponential growth in the rate of exponential growth† (Williams 2008) has been casually lounging on the desktops of tech savvy innovators for years now. However, over just the last few years we have seen how the motive forces of Globalism have actually worked to push this insipient new reality into the forefront of technological advance. In just the past year alone, the exponential growth of social networking and SMS technology with websites like Twitter, Delicious, Digg, and a host of others, which have seen an amazing growth in popularity, has simply leveled the playing field between the mulit-national corporation and the individual; in the delivery of news and information. For the first time, in a large way the internet, has trumped the corporate media in determining just what the content of the new 24 hour news cycle should contain. Often throughout this process of evolution we have seen independent internet news sites that have gathered first hand information well before the networks were ever aware its existence. Then, all of a sudden, there emerged a whole new group of independent reporters; information consultants if you will: â€Å"[The] [T]echie-types †¦ began to discover the power of the power of the Internet to amplify a single voice †¦ suddenly [they] gave this voice substance †¦ authority †¦ reach †¦ and influence like never before. In fact †¦ we have witnessed the rise of a whole new class of video journalists †¦ armed only with mobile phones †¦ who are changing the way we see the world †¦ from the violence in Tibet †¦ to gaffs on the [American] campaign trail †¦ Seemingly overnight †¦ [BBC] †¦ CNN †¦ Fox News and others †¦ have hundreds †¦ if not thousands †¦ of would-be colleagues and competitors across the globe. † (Sansalone, 2008) Completely independent of political tradition, it has suddenly become the internet that has often had the last word. The Beijing Olympics and the Presidential campaign overseas can now be seen as significant milestones that have helped to bridge the gap from the old to the new. Gone is the old school entrepreneur, pushing their way into the forefront of innovation, begging for a seat at table, the Infoperneur had come of age. If ever there was a time when you were not quite sure that you were actually living in The Information Age, today there should be little doubt in your mind. Make no mistake about it; this is the mega high-speed information world that they were telling us about. Thirty eight years after anthropologist Alvin Toffler prophesized the rapid insurgency of what was ultimately to become, a kind of post / super-industrial world, that was sure to leave most Western nations disconnected and suffering from a kind of â€Å"shattering stress and disorientation†, namely from something he called â€Å"future shock†, his vision of the world is now somewhat front and center and once again on full blast (Toffler, 1970). Toffler feared that we would not be able to adapt to the enormous mega-trends that were coming in the wake of an entirely New Age. He seemed to think that we would all somehow break down under the pressure of a kind of dystopian totalitarian rule, just like the characters in the James McTeigue political thriller V for Vendetta. Unable to reconcile the fascinating pace of the New Age, while we all wandered about Westminster Abbey in a daze, shuttering simply at the thought of having those dammed black bags thrown over our faces if we did not behave as the government wanted us to; this was a world that he believed was rapidly coming towards us. It was to present us with far too many choices than the average individual or family could ever withstand. Although he may have missed the mark a little on just how well the West would adapt, one thing is sure to have a potentially damaging effect upon us in the not too distant future. The foods that we are now consuming are not as fresh as they were back when Toffler wrote Future Shock nearly forty years ago. As a consequence, at some point, with the ever-increasing corporatization of the British diet, and with food standards growing more and more lax everyday, we are sure to pay a heavy price. Perhaps the time is at hand when the masses will seek out qualified ‘Infoperneurs’ online to help provide them with the knowledge of how to maintain a healthy diet; while living in an increasingly unhealthy environment. Nevertheless, Toffler was aware way back then that computers would have an enormous, if not ubiquitous impact upon shaping all of our lives. Even as he watched these trends develop, still he maintained an uncanny awareness that we had only touched upon what was the tip of a nearly unfathomable iceberg, â€Å"We have scarcely touche the computer revolu-tion and the far-ramifying changes that must follow churning in its wake† (Toffler, 1970). It is almost impossible to believe that anyone would have thought way back then that the number one currency for more than one billion people currently wired to the internet everyday, would simply be ‘information’. Twelve years after Toffler, another futurist published a book called Mega-Trends. This book by John Naisbitt remained on the Best Seller list for more than two years. Naisbitt was able to point his vision sharply into the future, and what he saw was a world of great transformation. He displayed a far greater sense than Toffler that the Western world would not only be able to weather the winds of change; but that we would for the most part welcome and embrace them. In 1982, Naisbitt predicted Ten Mega-Trends that he saw looming on the horizon. You tell me just how accurate he was. 1) He believed that we were becoming an information society after having been largely an industrial one. Looking at where we are today, it’s hard to believe that anybody could dispute that. 2) He believed that we were moving from technology being forced into use, to technology being pulled into use where it is appealing to people. Back then one could only imagine that the burden of having to use a computer at all was indeed challenging to some people; as I am sure it still is today. 3) Nesbitt predicted that globalization was quickly coming upon the horizon more than ten years before the word even came in vogue. He believed in 1982, that nations would evolve from predominantly national economies into a global marketplace. All of these changes would indeed develop shortly thereafter, and we must remember still, that this was relatively a short time ago. 4) He believed that we would move from short term to long term perspectives, and 5) from centralization in business and governance to decentralization. 6) Now this is where Nesbit predicted the emergence of Infopreneurship. He believed back then, that we would move away from getting help through institutions like government to self-help; and actually, 7) From representative to participative democracies. 8) Nesbit said that we would move from hierarchies to networking. He obviously saw the enormous trend towards social networking long before anyone seems to have thought about its full potential. 9) He said that our biases would dissipate. 10) Lastly, he predicted that we would evolve from seeing things as â€Å"either / or† to having a variety of choices. Now, who would have thought as much? The decade of the eighties would become a rich fertile ground for the emergence of a new intrapreneural boom that would begin to take shape by the mid 1990’s. However, the roots of many of the trends that both Toffler and Naisbitt wrote about actually began to take shape during the waning years of the Cold War. As Japan quietly began to re-emerge as a burgeoning economic powerhouse coming back upon the world scene more than 35years ago, they would carry with them a model of workplace innovation. It was common back then for Americans to comment that the Cold War was indeed over, and that it was actually the Japanese who had won it. In 1980, one out of every four cars in the U. S. market was Japanese. Japan started making better and cheaper cars than their American counterparts. They broke the back of the great American export leviathan and suddenly American businesses were forced to take a long hard look eastward at Japan. The world would take notice. This was to become an era that would give rise to a new emphasis upon developing a spirit of creative innovation within the workplace. Intrapreneurship was all of a sudden being greatly encouraged in the workplace. Gone was the marshal attitude of strict unquestionable control. The creative spirit was let loose to the point that a man named Art Fry at the 3M Company could gain inspiration from a co-worker, who invented an adhesive, yet could not find a thing to do with it. Fry had an epiphany after noticing that the book marks kept falling out of his church hymnals during choir practice. Lo and behold, Post-its stickers were born (Business Strategy 1988). During the same year that John Naisbitt was predicting the trends of the future, Norman Macrae was also speculating upon corporations discovering stimulating ways to develop creative ‘intrapreneurs’ within their firms. He believed that intrapreneural competition should be aggressively encouraged. Suddenly, in the face of declining sales in manufacturing, automobiles and electronics, due to the great efficiently of the burgeoning Japanese market (Japan is now the second largest economy in the world); other Western nations began to loosen their ties in the workplace. It was during that period as well that Gifford and Elizabeth Pinchot would first begin to coin the term ‘intra-peneur. ’ Together they wrote passionately about the workplace and their concept of the emerging future of Infopreneurship would become a prominent aspect of the lexicon of their work for years to come. [â€Å"We will begin facing the challenges caused by expanding technological power and growing population when we change what we are striving for. We need a new definition of success† (Pinchot, 1995)]. Together they took pains to give full credit for their ideas to the earlier work of Norman Macrae. In 1985 after developing their methods in Sweden, they actually started a school for Intrapreneurship. One year later, John Naisbitt was speaking of Intrapreneurship and a means for American firms to find new markets. The development of the Macintosh computer was described by Steve Jobs as an ‘intrapreneural’ venture. India would also re-emerge upon the world stage over just the last decade and a half largely as a result of their embrace of the concept of intrapreneurship. Later, in 1990, Rosabeth Moss Kanter of Harvard Business School spoke of ‘intrapreneurship’ in her book â€Å"When Giants Learn to Dance. â€Å" [â€Å"†¦. coaching to stimulate and guide the creation of new ventures from within. These strategies [that] [come] from the core of the post-entrepreneurial take entrepreneurial to the next step. †] (Kanter, 1990) While the concept of intrapreneurship was helping to develop the leaders of the near future internet technology boom in Silicon Valley; this would become yet another golden age of entrepreneurialship around the world. Within a relatively short period of time, Desktop Publishing had come into its own. In time, the home office, tele-commuting, Fed X Kinko’s Business Services, and private mailboxes would help to transform the face of small businesses all across the globe; making it more cost effective for ambitious individuals to strike out on their own as independent entrepreneurs. This era of innovation and enterprise roughly from the mid 1980’s to the turn of the New Century, would in turn help to plant the fertile seedlings for the Inforperneural Age of today. However first, the foundation of one great industry would appear on its way to becoming unhinged. While governments act to bail out banks during the economic downturn, and public sector funds are siphoned away from the till for the 2012 Olympics, Google is reporting a more than 25% third quarter jump in profit. Why, because the average Brit now gets their news at least three times a day from the internet. Those who are now taking advantage of the Web 2. 0 infrastructure, even while Web 3. 0 is on the launching pad, have become the new Infoperneurs. One might easily doubt that it could have been foreseen that the internet would actually force the worldwide restructuring of the newspaper industry. Job cuts are now being reported at the Cambridge News and The Independent, and overseas in just the last few years, a number of the most popular newspapers have been forced to cut their staffs, and many have eliminated whole sections from their papers altogether. In the wake of massive job cuts, the New York Times recently announced that its circulation was down 3. 9%. If that was not bad enough, on the heels of a deepening economic recession its advertising market has recently reported precipitous decline. Many other newspapers throughout the world are currently in the midst of perilous financial times. (The Economist, September 20, 2008) In March of this year the Newspaper Association of America admitted that the decline of newspapers across the country was actually happening more rapidly than it had been previously reported. At the same time online revenues for some papers were beginning to skyrocket. Total print revenues plummeted in 2007 down 9. 4% to $42 billion compared to the previous year. This reflects the single biggest drop in revenue since the year 1950, when the organization first started tracking quarterly revenue (Riley 2008). At the same time, we discover that: â€Å"Online [ traffic] [offered] some solace for the dead-tree business, with internet ad revenue growing 18. 8% to $3. 2 billion compared to 2006, but a rate significantly lower than the 31. 4% growth the year before, and not even close to replacing the losses from print. Online revenue now represents 7. 5% of total newspaper ad revenues† (Riley 2008). What is actually hidden behind the numbers is a totally new reality in the way that we view our world. The internet is now the single greatest marketplace for information. It is where people go the plug into any thought, concept, or idea that they may wish to learn more about. They press a button, and ‘poof’ there it is! Someone has to do all that research, post and retrieve all of those articles, and simply broker the non-stop flow of billions and billions of tiny little bits of information traveling across a seemingly endless world wide web. Gone are the days when a trusted source is a viable information consultant simply because he has graying hair (notice I said he! ) and sits behind a large oak desk. The internet is history’s greatest experiment in democratization; and that became evermore evident during the previous year than ever before. Recently, Google came out with a new browser named Chrome, which acts in direct competition with Microsoft’s internet browser, allowing for more individual manipulation and input of what amounts to an open source operating system (The Economist, September 6, 2008). The Universe is starting to bend towards individual will more and more each and everyday. No, the entrepreneur is not dead, nor will that great spirit of British ingenuity and drive ever disappear upon this planet as long as this nation survives. It is something that has always been ingrained within the spirit of the U. K. We could have never survived for so many centuries without it. Infoperneurs are just the latest breed of pioneers that’s all. They are not suffering during this economic downturn; you can believe that! They provide an invaluable service, because they are able to make use of the databases that make up the internet, as a way to actually leverage information by surveying and manipulating it in order to repackage and deliver it tailor-made towards the specificity of a variety of clients and or situations (Bouchard, 2000). This is what they do. It is the wave of the future. As the internet grows, the job of an Infoperneur promises to become evermore valuable; and oddly enough they will not even have to walk beyond their front door. Bibliography Author (s) Journal of Business Strategy (1988) Lessons From a Successful Intrapreneur: An Interview With Post-it Notes Inventor Art Fry:. MCB UP Ltd. Volume 9: Issue 2 Page: 20-24. Retrieved from: http://www. emeraldinsight. com/10. 1108/eb039208 Du Toit, Adeline (2000). Teaching Infopreneurship: Students’ Perspectives. Aslib Proceedings. Bradford: Feb 2000, vol. 52, Issue 2; pp. 83-91. The Economist. (September 20, 2008) Slim Hopes: Newspapers in America. A Billionaire Makes A Surprising Investment In the New York Times. Volume 388 Number 8598 78-79 The Economist. (September 6, 2008) Google’s New Web browser: The Second Browser War: Google’s New Web Browser is its most direct attack on Microsoft yet. Volume 388 Number 8596 72-73

Growth Hormone In Tooth Development Health And Social Care Essay

Growth Hormone In Tooth Development Health And Social Care Essay Tooth development is the process where teeth are formed from the developing tooth bud, growing and maturing until it erupts into the mouth. This process is known as odontogenesis. There are several stages to odontogenesis which include the development of the tooth bud and the formation of hard tissue (Thesleff 2006). Within this paper, I will be discussing whether growth hormone has an effect on the development of the tooth bud and formation of hard tissue (in particular enamel and dentine formation). Growth hormone (GH) is produced by the pituitary gland, which is stimulated or inhibited by growth hormone releasing hormone (GHRH) and somatostatin respectively in the hypothalamus. GH stimulates the liver, for the production of insulin-like growth factor (IGF-1) (Laron et al citied by Laron Z. 2001); this has an effect on bones (particularly long bones) and muscles and other tissue growth. Gotz el al (2006) says that IGFs are growth factors controlling pre- and post natal development and growth processes. Furthermore, IGF-1 and GH are able to induce bone morpogenic proteins (BMP) messenger RNA (mRNA), in particular BMP-2 and 4 mRNA(Li et al 1998). The study that was carried out showed that GH and IGF-1 increased the production of BMP-2 mRNA by up to 5-fold and BMP-4 mRNA by up to 4-fold. In the developing tooth bud, there are four main stages; these include: the bud stage, the cap stage, the bell stage and crown stage. Figure 1: A schematic drawing of the bud stage the arrow shows the formation of the tooth bud (tb) within the dental lamina (dl) where dental mesenchyme (dm) has condensed around the tooth bud (Adapted from Joseph et al 1994) dl dm The bud stage is the tooth bud appearance, however, there is no arrangement of the cells figure 1 illustrates this stage showing that this stage is just a group of cells by the dental lamina. Li and colleagues (1998) carried out a study which showed that BMP-4 mRNA was present in the dental epithelium during this stage until the cap stage. This suggests that BMP-4 is needed for the cells so that they are able to combine and form the dental papilla from this unorganised arrangement. In addition to this, GH and its receptor was reported to be involved in allow process like induction, epithelial-mesenchymal interactions, cellular proliferation (Zhang et al 1997). The study was able to show that GH was present at embryonic day 17/18 in the rat, which represents the bud stage of odontogenesis in the rat. However, a study conducted by Zhang and colleagues (1992) brought up a very important point. This being that the pituitary gland is still forming when tooth bud formation occurs. Thus, if the gland is still forming, GH would not be able to play a role during the bud stage. Therefore, it is possible that a GH-like molecule might be involved during the bud stage; however, it has not been confirmed. The cap stage is when ectomesenchymal cells combine and become the dental papilla. Additionally, the tooth bud begins to grow around the ectomesenchymal cells, combine producing a cap appearance and becomes the dental (or enamel) organ. Eventually the dental papilla will produce dentine (and pulp) and the enamel organ will produce enamel. It is shown that during the cap stage numerous cells of the dental epithelium and mesenchyme were intensely immunoreactive for GH (Zhang et al 1997). This suggests that GH is involved in the formation of the enamel organ and dental papilla, which are needed to form enamel and dentine respectively. Furthermore, studies (Joseph et al 1994) found out that GH receptors were Figure 2: A schematic drawing of the late cap stage showing the dental follicle (df) containing the dental/enamel organ and dental papilla (dp). The dental/enamel organ is starting to differentiate into the outer dental epithelium (ode) and inner dental epithelium (ide). (Adapted fro m Joseph et al 1994) dp expressed in the epithelium (where the enamel organ is located) and also in ectomesenchymal cells (where the dental papilla is located). Thus, showing that the receptors for GH are present indicating that GH is able to activate the receptors which are needed to activate the cells. This evidence both support the idea that GH is needed for the differentiation of ectomesenchymal cells to form the dental papilla and dental organ. Figure Figure 3: A schematic drawing of the bell stage: Differentiation of the dental/enamel organ and dental papilla (dp) occurs. The enamel oragn differentiates into the outer dental epithelium (ode), inner dental epithelium (ide), stellate reticulum (sr) and stellate intermedium (si). The dental papilla differentiates into the outer and central mesenchymal cells of the dental/enamel organ. The bell stage (named because the dental organ is shaped as a bell) is when histodifferentiation and morphodifferentiation of the dental papilla and enamel organ take place. Joseph and his colleagues (1994) showed that in the early period of the bell stage, there is growth of the dental organ, as cubical inner epithelium differentiates into columnar cells. Additionally, immunoreacitivity for GH receptor/binding protein found that the outer and inner enamel epithelium and stratum intermedium were positive, signifying that the growth hormone receptor is involved in the differentiation of the enamel organ. This in turn allows the inner enamel epithelium to differentiate into ameoblasts, outer enamel epithelium to provide a protective barrier during enamel production and finally, stratum intermedium is needed for enamel production to occur. However, the dental papilla and stellate reticulum were negative for immunoreactivity of GH receptor/binding protein. This suggests that dental papil la does not need GH to differentiate nor does the stellate reticulum which is needed as support for enamel production. The tables below (table 1 and 2) summarises the immunoreactivity expression of growth hormone at various stages of tooth development, including the bud and cap stage. It is clearly shown that in the stages for developing tooth germ, GH, its receptor and binding protein are expressed in various cells throughout the stages. Table : Immunoreactivity expressed in the epithelium of a embryonic rat mandible showing the presence of GH, GH receptor and GH binding protein during embryonic day 17, 16, 20/21 and post natal day 9. The results are recorded show the intensity of the expression: +++ STRONG, ++ MODERATE, + MILD +/- EQUIVOCAL (Zhang et al 1997) Table 2: Immunoreactivity expressed in the mesenchyme of a embryonic rat mandible showing the presence of GH, GH receptor and GH binding protein during embryonic day 17, 16, 20/21 and post natal day 9. The results are recorded show the intensity of the expression: +++ STRONG, ++ MODERATE, + MILD +/- EQUIVOCAL (Zhang et al 1997)The finally stage of the developing tooth bud is the crown (or maturation) stage. This is when the hard tissue (enamel and dentine) start to develop. Thus, the inner enamel epithelial cells start to change shape and differentiate into ameloblasts and the dental papilla changes in both size and shape and differentiate into odontoblasts to form dentine. This leads to the two processes commonly known as amelogenesis (formation of enamel) and dentinogenesis (formation of dentine). Symons et al (2000) showed that there immunoreactivity of the IGF-1 receptor present during the maturation of the ameloblasts. Thus, it indicates that IGF-1 (via its receptor) is involved during amelogenesis. This shows that IGF-1 is needed for the ameloblasts to remove organic material and water (Nanci et al 1987), with increased flux of calcium and phosphate ions (Borke et al 1993) Caviedes-Bucheli et al (2009) study was investigating real time PCR in mouse pulp cultures. The found out that IGF-1 can enhance the mineralisation of enamel ( dentine). The way it was able to do this was by inducing expressions of specific genes (Caton et al 2005) In addition to is, Caton et al (2005) was investigating the effect that IGF-1 would have on tooth development in vitro. The results showed that the samples treated with IGF-1 had an increased enamel extracellular matrix, when compared to the control samples. This shows that there is increased enamel and dentine when IGF-1 was present, indicating that IGF-1 has a positive effect on the enamel and dentine formation. The majority of the studies show the presence of GH and its receptor within cells. Smid and colleagues (2007) carried out an experiment when mouse molar teeth had a GH deficiency. The results shows that when there is a deficiency the crown dimensions were affected as the total crown area and the mesiodistal width at the cement-enamel junction (CEJ) was significantly smaller, when compared to when GH was present. This indicates that GH is needed to ensure growth of the tooth enamel and dentine, and when there is a deficiency, it affected the size of molar teeth. Crown formation is finished when the inner enamel epithelium and outer enamel epithelium forms a double layers of HERS. This starts to proliferate apically and starts root morphogenesis. Yamashiro et al (2003) found out that BMP-2, -3, -4 and -7 were expressed during root formation and was associated with the differentiation of hard tissues. In particular, BMP-4 and -7 were expressed in ameloblasts which indicate that they are needed for formation of enamel. Furthermore, expression of BMP-4 was also noted in cementoblasts which is needed for the production of primary acellular cementum and secondary cellular cementum (where acellular cementum is found on the cervical third and middle of the roots and attaches to principle fibres in the periodontal ligament and cellular cementum is located on the apical third of the root Cho Grant 2000 citied in Yamashiro et al 2003). The purpose of the cementum, which is a thin layer of mineralised tissue, is to attach the periodontal ligament in the gingiva to the surface of the root (Smid et al 2004) One of the final stages of tooth development is the eruption of the tooth. Studies were carried out on rat incisor teeth which showed that when the incisor tooth erupted, IGF-1 was expressed in the odontoblasts and ameloblasts, as well as its receptor (Joseph et al 1993, 1994, 1996 citied in Fukunaga et al 2008). Thus the evidence suggests that IGF-1 is needed during the final stages of the amelogenesis and dentinogenesis. A major limitation within the researching of the papers was the fact that experiments and studies were carried out on rat teeth. Thus, there teeth are not the same to human teeth. Moreover, a small proportion of the papers were based on human teeth, were the study was carried out on teeth belonging to people with a defect (for example Fukunaga et al 2008 had their study carried out on a patient with leprechaunism). However, from researching the papers, it is evident that GH or GH-like molecules (like IGF-1 and BMP 2 and 4) are present within the different stages of odontogenesis, depicts the lack of information relating to human teeth. Evidence has shown that expression during various stages of tooth development. Furthermore, when there is a deficiency of GH, there are changes within the tooth structure when erupted. Thus, I can conclude that GH does play a role in tooth development, in particular during the tooth germ stages, amelogenesis and dentinogenesis. However, more research n eeds to be conducted to clearly show GH expression and its role in human teeth during its development pre and postnatal.